Recently, the research team of nanometer medicine and molecular diagnosis and treatment in our university has constructed a new kind of oxygen-carrying biomimetic nano-material based on Zr-based MOF(UiO-66), bonding indocyanine green (ICG), the photosensitizer, to the surface of UiO-66 through coordination with method of post-modification, using whose porous structure to load oxygen, wrapping erythrocyte membrane on the surface to composite photodynamic therapeutic reagent O2@UiO-66@ICG@RBC with the function of immune escaping and self oxygen supplying. The study offers a passive targeted delivery method of oxygen and photosensitizer. The nano-material can improve hypoxic status of solid tumors and enhance photodynamic therapeutic effect at the irradiation of 808nm near-infrared light (as shown below). The related research results were published on Biomaterials (2018, 178, 83-94). Hebei University was the first completion unit.  Gao Shutao, a PHD candidate of 2017, from School of Chemistry and Environmental Science, is the first author of the paper. Associate Professor Li Zhenhua, Professor Zhang Jinchao from this college, and researcher Liang Xingjie from National Nano-science Center of Chinese Academy of Sciences, are all corresponding author of the thesis. This is another work of the research team since the publication of two paper in Biomaterials (Biomaterials, 2017, 122, 23-33; Biomaterials, 2017, 144, 155-165)  in 2017. The research results will play an active role in expanding

the application of MOF materials in the biomedical field. The research was funded by the National Natural Science Foundation

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